Families

ALSP Overview

•    Clinical Features (What Happens to Patients?)
（1）Brain Problems:
a) Memory loss, trouble thinking (like "brain fog")
b) Mood changes (depression, irritability) or even hallucinations
c) Movement issues (stiff muscles, tremors, trouble walking)

（2）Gets Worse Over Time:
a) Starts in adulthood (usually 30s-50s)
b) Progresses to severe disability (wheelchair-bound, unable to speak/swallow)

•    How Rare Is It?
（1）The incidence is low: 300 cases per million.
（2）Often misdiagnosed as Alzheimer’s, Parkinson’s, or MS early on.

•    How Is It Inherited?
（1）Single Faulty Gene: Caused by mutations in the CSF1Rgene.
（2）Family Risk:
a) If a parent has it, each child has a 50% chance of inheriting it.
b) Many cases happen randomly (de novo) with no family history.