The symptoms of MPS VII can vary widely. In the most severe cases, it can be seen before birth with a condition called hydrops fetalis, which can be life-threatening. In milder cases, children may live into adulthood. Common signs include slower growth after birth, short stature, and distinctive facial features such as a large head, thick eyebrows, a wide nose, large tongue, widely spaced teeth, and a prominent jaw. Children may also have hearing loss and cloudy corneas, which can affect vision.
Heart problems, breathing difficulties, and frequent lung infections can also occur. Some children may have an enlarged liver or spleen, or hernias in the belly area. Bones and joints are often affected, leading to spine and hip problems, curved bones, joint stiffness, and foot abnormalities like clubfoot. Many children have developmental delays, learning difficulties, trouble speaking, and may experience progressive changes over time.
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