Neurodevelopmental problems and craniofacial abnormalities are frequently observed in individuals with MAP4K4-related disorders. The incidence rates observed in previous reports are as follows:
Neurodevelopmental delay (HP:0012758): 83%
Intellectual disability (HP:0001249): 42%
Short stature (HP:0004322): 35%
Brain imaging abnormality (HP:0410263): 39%
Congenital heart defect (HP:0001627): 28%
Attention deficit hyperactivity disorder (HP:0007018): 26%
Seizures (HP:0001250): 24%
Hypotonia (HP:0001252): 22%
Autism (HP:0000717): 24%
Abnormal facial skeleton morphology (HP:0011821): 25%
Abnormality of limbs (HP:0040064): 25%
Abnormality of the genitourinary system (HP:0000119): 25%
Abnormality of the gastrointestinal tract (HP:0011024): 17%
Hemangioma (HP:0001028): 8%
MAP4K4