Management

Management of Autosomal Recessive Spastic Paraplegia Type 45 (ARSPG45) is exclusively symptomatic, focusing on reducing spasticity and improving gait and strength. Key interventions include physical therapy and occupational therapy to maintain muscle function and flexibility, various oral medications such as baclofen and tizanidine to relieve spasticity, and botulinum toxin injections for more localized muscle issues. In severe cases, an intrathecal baclofen pump may be considered. Supportive measures like orthotics and mobility aids also play a crucial role.