Management

Monitoring of metabolic complications from age 12y by endocrinologist:
•    Treat insulin resistant diabetes and dyslipidaemia (consider leptin treatment in case of insufficient results with standard of care)
•    Monitor liver steatosis
•    Manage cardiovascular risk factors: avoid smoking, advise healthy diet, treat hypertension

Monitoring of neurological complications:
•    Monitor developmental progress during childhood. In the presence of developmental delay, provide comprehensive support including rehabilitation, speech and language therapy, occupational and physical therapy, and psychological or educational interventions as appropriate.
•    Yearly neurological evaluation