TCF7L2-related neurodevelopmental disorder (TRND) is a rare condition that affects brain development. It is caused by a change in the TCF7L2gene and usually appears in early childhood.
Children with this condition may have delayed development, especially in learning, speech, and motor skills, with many children showing improvement over time. In some children—both boys and girls— features of autism or ADHD may be present. Vision problems and mild physical differences may also occur. Not all individuals have the same symptoms, and the severity can vary widely.
The condition follows an autosomal dominant pattern, meaning that a change in only one copy of the gene is sufficient to cause the disorder. All mutations discovered so far were new mutations in the affected child and were not inherited from either parent.
Because this is a newly described and very rare condition, the number of known cases is small, and the full range of possible features is still being studied.
TCF7L2