PhenomeGene — Human Disease Gene Website SeriesUBAP1

Clinical Characteristics

Neurological symptoms
•    Leg stiffness and weakness:the most common sign.
•    Walking problems: legs may feel tight, and steps may become smaller or unsteady.
•    Reflexes: doctors may notice "hyperactive" reflexes, more frequently in the lower limbs.
•    Bladder symptoms:like needing to urinate urgently.
•    Other possible symptoms:mild numbness or tingling in the feet (rare).
•    No significant learning or cognitive problems are expected.