Families

The CMIPgene is found on chromosome 16 and studies have shown that CMIPmay be linked to language development, reading skills, and general learning ability. Changes in this gene can therefore affect how the brain develops and functions.

People with CMIP-related conditions can have a wide range of developmental and behavioral differences. These often include developmental delay, autism-related features, attention problems or hyperactivity (ADHD), and other emotional or psychiatric difficulties. Some individuals also develop epilepsy, but seizures that are difficult to treat appear to be relatively uncommon.

To better understand how CMIPaffect the brain, a zebrafish model carrying a harmful CMIPvariant was generated. These zebrafish showed abnormal movement patterns and seizure-like brain activity, supporting the idea that CMIPplays an important role in normal brain development and brain signaling. Together, findings from affected individuals and the zebrafish model show that CMIPis involved in neurodevelopmental and neuropsychiatric disorders.